Translational Grant Program

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The Office of Discovery and Translation (ODAT) Translational Grant Program helps drive research that translates basic science discoveries into patient benefit, with the overarching goal of improving human health.

In addition to funds, awarded projects will also receive the support of a project development team with the appropriate expertise to help determine project milestones, identify key gaps, and strengthen the project’s likelihood of advancing toward new therapeutics, diagnostics, devices, or treatment approaches.

Apply for funding

The program’s latest grant cycle application period has closed. View the 2017 RFA that exclusively focused on rare diseases. 

Examples of applicable projects   

This funding program is intended to identify and fund early-stage projects in which the primary goal is to eventually develop a new therapeutic, diagnostic, medical device, or treatment approach. 

Eligible project types include, but are not limited to:

  • Identification of a small molecule or biologic with potential for therapeutic effect.
  • Moving from concept to initial design of a new medical device.
  • Definition of differential expression of specific biomarkers for diagnosis or treatment purposes.
  • Development of new models of human disease that could be used in the testing of therapeutics, diagnostics, devices, or treatment approaches specific to rare diseases.

Read about the types of projects we prioritize.

Awardees

2016

Mikael Elias, PhD, Assistant Professor, College of Biological Sciences 

Project title: A new technology to control microbes and increase the effectiveness of GI endoscope disinfection procedures


Gary Goldish, MD, Assistant Professor, Department of Rehabilitation Medicine, Medical School, and Adjunct Professor at the Minneapolis VA Health Care System

Project title: Development of an arm cycle ergometer for supine use

2014

Conrado Aparicio, PhD, School of Dentistry, Department of Restorative Sciences 

Project title: GL13K Antimicrobial Peptide Coatings with Strong Resistance to Degradation and Sustained Activity for Preventing Dental Peri-implant Infection


Shai Ashkenazi, PhD, College of Science and Engineering, Department of Biomedical Engineering

Project title: Depth-resolved Tissue Oxygen Needle Sensor


Arthur Erdman, PhD, College of Science and Engineering, Department of Mechanical Engineering, Medical Devices Center

Project title: Acoustic Modulation of the Phrenic Nerve for Treatment of Ventilator Induced Diaphragmatic Dysfunction


Benjamin Hackel, PhD, College of Science and Engineering, Department of Chemical Engineering & Materials Science

Project title: Molecular PET Imaging of MET with Small Protein Ligands


Alexander Khoruts, MD, Medical School, Department of Medicine

Project title: Development of Immunoregulatory Microbiota to Suppress Gut Inflammation


Jayanth Panyam, PhD, College of Pharmacy, Department of Pharmaceutics

Project title: A Novel Marker for Isolation and Characterization of Circulating Tumor Cells from Patients with Metastatic Cancer


Srinand Sreevatsan, BVSc, MVSc, MPH, PhD, College of Veterinary Medicine, Department of Veterinary Population Medicine 

Project title: Point-of-care Detection and Monitoring System for Tuberculosis

2013

John Bischof, PhD, College of Science and Engineering, Department of Mechanical Engineering

Project title: Improved Disease Diagnosis Using Lateral Flow Assays with Thermal Contrast


Deborah Ferrington, PhD, Medical School, Department of Ophthalmology and Visual Neurosciences

Project title: Enhancing Mitochondrial Function as a Treatment for Age-Related Macular Degeneration


Allison Hubel, PhD, College of Science and Engineering, Department of Mechanical Engineering

Project title: Microfluidic Device for Removal of DMSO from Frozen and Thawed Cell Therapy Products


Hubert Lim, PhD, College of Science and Engineering, Department of Biomedical Engineering

Project title: A New Noninvasive Approach for Brain Activation to Treat Tinnitus


Paula Ludewig, PhD, PT, Medical School, Department of Physical Medicine and Rehabilitation

Project title: Shoulder Motion Guided Patient Diagnostic and Treatment Classification


Robert Tranquillo, PhD, College of Science and Engineering, Department of Biomedical Engineering

Project title: Preclinical Evaluation of a Novel Tissue-engineered Heart Valve

2012

Cycle 1

Khalil Ahmed, PhD, Medical School, Department of Laboratory Medicine and Pathology

Project title: Cancer Nanotherapeutic Targeting CK2


Deborah Ferrington, PhD, Medical School, Department of Ophthalmology and Visual Neurosciences

Project title: Enhancing Mitochondrial Function as a Treatment for Age-Related Macular Degeneration


Erik Finger, MD, PhD, Medical School, Department of Surgery

Project title: Isolation and Expansion of Regulatory T Cells from Patients with End Stage Liver Disease for the Induction of Tolerance in Transplantation


Jafar Golzarian, MD, Medical School, Department of Radiology

Project title: Pharmacokinetic and Safety of Doxorubicin-Elutable Bioresorbable Microspheres in a Rabbit Model of Hepatic Arterial Embolization


Marc Jenkins, PhD, Medical School, Department of Microbiology and Immunology

Project title: Hepatitis B Conjugate Vaccine


Steven Patterson, PhD, and Louis Mansky, PhD, Center for Drug Design, Institute for Molecular Virology

Project title: Investigation of HIV-1 Lethal Mutagenesis in a Humanized HIV Mouse Model


Rita Perlingeiro, PhD, Medical School, Department of Medicine

Project title: Therapeutic Approaches for Duchenne Muscular Dystrophy using iPS Cells


David Potter, MD, PhD, Medical School, Department of Medicine

Project title: Epoxygenase Mechanisms of Breast Cancer Prevention


Cycle 2

Peter Dosa, PhD, College of Pharmacy, Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development

Project title: Development of Novel Therapeutics for Glaucoma


Michael Linden, MD, PhD, Medical School, Department of Laboratory Medicine and Pathology

Project title: Identifying Immunophenotypic Markers Suitable for Clinical Laboratory Testing for Early Identification of Bortezomib Resistance in Human Multiple Myeloma


Ann Parr, MD, PhD, Medical School, Neurosurgery Department

Project title: Autologous OPCs for Transplantation into Human Spinal Cord Injury


Valerie Pierre, PhD, College of Science and Engineering, Department of Chemistry

Project title: Siderophore Aptasensors for Immediate Point-of-care Diagnosis of Urinary Tract Infection

Contact us

Sandra M. Wells, Ph.D.
Assistant Director
smwells@umn.edu
612-625-3073

Jodi Fenlon Rebuffoni
Project Manager
Office of Discovery and Translation
fenl0003@umn.edu
612-626-6945

Grantee successes

Valerie PierreHow CTSI is helping one University investigator convert her idea into a real-world tool for diagnosing infections

More grantee stories:

CTSI grantee's cancer treatment device amasses $8 million in financing over two years

CTSI support helped advance University of Minnesota start-up company