Translational Research Development Program

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The Translational Research Development Program (TRDP) aims to provide an opportunity for early stage investigators to gain significant experience with clinical and translational research.  The program is available to predoctoral trainees, postdoctoral trainees and medical fellows and provides research funds up to $16,000 available over two years.

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Program overview
    • Expanded its eligibility criteria and is available to:
      • Predoctoral trainees pursuing a PhD in a PhD graduate program or PhD dual degree program who have passed their written and oral preliminary examinations
      • Postdoctoral trainees, including medical fellows, who are no more than 3 years into their postdoctoral training.
    • Aims to provide an opportunity for early stage investigators to gain significant experience with clinical and translational research.
    • Research funds up to $16,000 available over two years
    • Requires a primary research mentor and a translational mentor, such as a senior faculty member or biostatistician, who will help guide and advise the TRDP project
Application details
This program is not currently accepting applications. View application information from the previous cycle:
Program deadlines
    • February 12, 2015 (noon): LOI due
    • February 19, 2015: Invite full proposals
    • April 2, 2015 (noon): Full proposals due
    • June 1, 2015: Program start date  
Nature and purpose of this RFA

The Clinical and Translational Science Institute (CTSI) will provide institutional research funds for predoctoral and postdoctoral trainees with a demonstrable and significant interest in clinical or translational research focused on human health. The program aims to provide an opportunity for early stage investigators to gain significant experience with clinical and translational research as a foundation for the development of an independent research career focused on human health.

Funds are designed to support a modest research project that will result in a publication in a peer reviewed journal. The TRDP project is secondary to the applicant’s primary research endeavors and must advance the trainee’s research along the clinical and translational research spectrum (see below). For example, a TRDP project for a trainee currently conducting basic research (T0) should be in the T1, T2, T3, or T4 translational categories. Similarly, a trainee currently conducting health services research (T3) should develop a TRDP project that demonstrates a clear movement toward the T4 category.

Current scholars

Mariam Ahmed, MS
Primary mentor: Richard Brundage
TRDP mentor: Gerald Raymond
Project title: A Model-based Approach to Optimize Lorenzo's Oil Therapy in X-Linked Adrenoleukodystrophy

Tyler Bosch, PhD
Primary mentor: Lisa Chow
TRDP mentor: Patrick Bolan
Project title: The Effect of High Intensity Interval Training on Liver Fat and Insulin Sensitivity in Adults with Obesity

Nicholas Brady
Primary mentor: Kathryn Schwertfeger
TRDP mentor: Douglas Yee
Project title: JAK Inhibition Disrupts Inflammatory Homeostasis in Human Macrophages

Michael Burns, PhD
Primary mentor: Ran Blekhman
TRDP mentor: Timothy Church
Project title: Using Virulence Genes in Stool as Markers of Colorectal Cancer

Jeff Flynn, PhD
Primary mentor: Ryan Hunter
TRDP mentor: Jordan Dunitz
Project title: Anaerobic bacterial consortia sustain the growth of pathogens in the upper airways of cystic fibrosis patients

Diego Garcia-Huidobro, MD
Primary mentor: Michele Allen
TRDP mentor: Iris Borowsky
Project title: Feasibility of a One-To-One Parenting Intervention to Prevent Substance Use in Latino Youth

Christopher Janson, MD
Primary mentor: Cornelius Lam
TRDP mentor: Gunda Georg
Project title: High-Throughput Discovery with Unique Alzheimer's Cellular Model

Sakeen Kashem, BA
Primary mentor: Daniel Kaplan
TRDP mentor: Maria Hordinksy
Project title: Langerhans cell function in controlling fungal immunity and commensalism

Liliane Mukaremera, PhD
Primary mentor: Kirsten Nielsen
TRDP mentor: David Boulware
Project title: Alteration of the innate immune response by different Cryptococcus neoformans morphologies in HIV and healthy individuals

Emily Pisetsky, PhD
Primary mentor: Scott Crow
TRDP mentor: John Hughes
Project title: Negative Affect and Substance Use as Momentary Mechanisms of Suicidality in Eating Disorders

Justin Ryder, PhD
Primary mentor: Aaron S. Kelly
TRDP mentor: Kyle Rudser
Project title: Longitudinal assessment of novel biomarkers for predicting cardiovascular disease in youth

Anja Srienc
Primary mentor: Eric Newman
TRDP mentor: Matthew Hunt
Project title: Cortical Spreading Depression as a Biomarker of Brain Injury During Neurosurgery

Alena Svatkova, MD
Primary mentor: Igor Nestrasil
TRDP mentor: Kyle Rudser
Project title: Revealing the Core of White Matter Alteration and Cognitive Deficits in Mucopolysaccharidosis Type 2

Elizabeth Thompson, MS
Primary mentor: Eric A. Hendrickson
TRDP mentor: Jakub Tolar
Project title: Gene therapy for Fanconi anemia using Cas9/CRISPR-mediated gene targeting

Diana Wallin, BS
Primary mentor: Michael K. Georgieff
TRDP Mentor: Gregory Vercellotti
Project title: The effect of recombinant human erythropoietin (RhEpo) therapy on the hippocampus of anemic neonatal mice

Tonya Ward, PhD
Primary mentor: Cheryl A. Gale
Project title: Infant Fungal Microbiome and Allergic Disease Development

Andrea Wolf, BS
Primary mentor: Greg Beilman
TRDP mentor: Raj Suryanarayanan
Project title: Formulation Optimization of a Low-Volume Resuscitation Fluid for Hemorrhagic Shock

Former scholars

Daniel Beisang, BS
Primary Mentor: Michael Georgieff
Project title: Quantitative Assessment of the Diversity of the Neonatal T cell Repertoire

Caroline Diep, BS, BA
Primary Mentor: Peter Argenta
Project title: En vivo modeling of primary ovarian cancer cells in 3D culture systems

Anne Frosch, MD
Primary Mentor: George Ayodo
Project title: The effect of HIV infection on malaria specific B cell subset frequency

Benjamin Hanisch, MD
Primary Mentor: Gregory Vercellotti
Project title: Impact of Iron Supplementation on Oxidative Stress in Children Recovering from Severe Malaria

Rachel Hardeman, PhD, MPH
Primary mentor: Diana Burgess
Project title: Racial/Ethnic Disparities in Birth Outcomes: Examining the Role of the Patient/Provider Relationship

David Knorr, BS
Primary Mentor: Michael Verneris
Project title: Evaluation of the CD4+ T cell response against influenza following hematopoietic cell transplantation

Jessica Musselman, MS
Primary Mentor: Julie Ross
Project title: Methylation of the BMP/TGFβ pathway and correlation with survival in childhood germ cell tumors

Alexa Pragman, MD, PhD (current CTSI KL2 scholar)
Primary Mentor: Chris Wendt
Project title: Comparison of the Oral and Lung Microbiota in Chronic Obstructive Pulmonary Disease

Brent Sorenson, MS
Primary Mentor: Rajaram Gopalakrishnan
Project title: Tumor-targeted reduction of hyopxia-inducible factor in oral carcinoma by calprotectin

Alexa Weingarden, BA
Primary Mentor: Alexander Khoruts
Project title: Bacterial Bile Acid Metabolism in Fecal Transplantation Treatment of Clostridium difficile Infection